ALOX5 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of ALOX5.
Immunogen
A synthetic peptide corresponding to human ALOX5.
Sequence
C-ERNKKKQLPYYYLSPD
Host
Goat
Theoretical MW (kDa)
78
Reactivity
Human, Rat
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Western Blot (0.3-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
ALOX5 polyclonal antibody (Cat # PAB7097) (0.3 ug/mL) staining of rat stomach lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — ALOX5
Entrez GeneID
240Protein Accession#
NP_000689.1Gene Name
ALOX5
Gene Alias
5-LO, 5-LOX, 5LPG, LOG5, MGC163204
Gene Description
arachidonate 5-lipoxygenase
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. [provided by RefSeq
Other Designations
OTTHUMP00000019502|arachidonic acid 5-lipoxygenase|leukotriene A4 synthase
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Interactome
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Pathway
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Disease
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Publication Reference
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ALOX5 promoter genotype, asthma severity and LTC production by eosinophils.
Kalayci O, Birben E, Sackesen C, Keskin O, Tahan F, Wechsler ME, Civelek E, Soyer OU, Adalioglu G, Tuncer A, Israel E, Lilly C.
Allergy 2006 Jan; 61(1):103.
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ALOX5 promoter genotype, asthma severity and LTC production by eosinophils.
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