CDC25A polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of extracts from A2780 cells using CDC25A polyclonal antibody (Cat # PAB5284) .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CDC25A.
Immunogen
A synthetic peptide corresponding to residues surrounding S75 of human CDC25A.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from A2780 cells using CDC25A polyclonal antibody (Cat # PAB5284) . -
Gene Info — CDC25A
Entrez GeneID
993Gene Name
CDC25A
Gene Alias
CDC25A2
Gene Description
cell division cycle 25 homolog A (S. pombe)
Omim ID
116947Gene Ontology
HyperlinkGene Summary
CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
M-phase inducer phosphatase 1|cell division cycle 25A|dual specificity phosphatase CDC25A
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Interactome
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Pathway
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Disease
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Publication Reference
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SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase.
Jin J, Shirogane T, Xu L, Nalepa G, Qin J, Elledge SJ, Harper JW.
Genes & Development 2003 Dec; 17(24):3062.
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Chk1 is activated transiently and targets Cdc25A for degradation at the Xenopus midblastula transition.
Shimuta K, Nakajo N, Uto K, Hayano Y, Okazaki K, Sagata N.
The EMBO Journal 2002 Jul; 21(14):3694.
Application：WB-Ti, Xenopus, Unfertilized eggs, Embryos.
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SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase.
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