APP polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of APP.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human APP.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
ELISA (1:1000)
Western Blot (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western blot analysis of APP (arrow) using rabbit APP polyclonal antibody (Cat # PAB4899). 293 cell lysate (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the APP gene (Lane 2) (Origene Technologies).Enzyme-linked Immunoabsorbent Assay
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Gene Info — APP
Entrez GeneID
351Protein Accession#
A4_HUMANGene Name
APP
Gene Alias
AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN2
Gene Description
amyloid beta (A4) precursor protein
Gene Ontology
HyperlinkGene Summary
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq
Other Designations
A4 amyloid protein|amyloid beta A4 protein|amyloid-beta protein|beta-amyloid peptide|cerebral vascular amyloid peptide|peptidase nexin-II|protease nexin-II
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Interactome
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Disease
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Publication Reference
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Platelet amyloid precursor protein abnormalities in mild cognitive impairment predict conversion to dementia of Alzheimer type: a 2-year follow-up study.
Borroni B, Colciaghi F, Caltagirone C, Rozzini L, Broglio L, Cattabeni F, Di Luca M, Padovani A.
Archives of Neurology 2003 Dec; 60(12):1740.
Application:WB, Human, Human platelets.
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Nonsteroidal anti-inflammatory drugs can lower amyloidogenic Abeta42 by inhibiting Rho.
Zhou Y, Su Y, Li B, Liu F, Ryder JW, Wu X, Gonzalez-DeWhitt PA, Gelfanova V, Hale JE, May PC, Paul SM, Ni B.
Science 2003 Nov; 302(5648):1215.
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Notch1 competes with the amyloid precursor protein for gamma-secretase and down-regulates presenilin-1 gene expression.
Lleo A, Berezovska O, Ramdya P, Fukumoto H, Raju S, Shah T, Hyman BT.
The Journal of Biological Chemistry 2003 Nov; 278(48):47370.
Application:WB-Tr, Mouse, N2a cells.
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Platelet amyloid precursor protein abnormalities in mild cognitive impairment predict conversion to dementia of Alzheimer type: a 2-year follow-up study.
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