PTPN6 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells) Lane 2: NBT-II cell lysate (Rat Wistar bladder tumour cells) with PTPN6 polyclonal antibody (Cat # PAB29368) at 1:100-1:250 dilution.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human lymph node with PTPN6 polyclonal antibody (Cat # PAB29368) shows strong cytoplasmic positivity in reaction center cells and lymphoid cells outside reaction centra at 1:200-1:500 dilution.
Immunofluorescence
Immunofluorescent staining of human cell line MCF-7 with PTPN6 polyclonal antibody (Cat # PAB29368) at 1-4 ug/mL concentration shows positivity in nucleus and nucleoli.
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant human PTPN6.
Immunogen
Recombinant protein corresponding to human PTPN6.
Sequence
HAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQESEYGNITYPPAMKNAHAKASRTSSKHKEDVYENLHTKNKREEKVKKQRSADKEKSKGSLK
Host
Rabbit
Reactivity
Human, Rat
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:200-1:500)
Immunofluorescence (1-4 ug/mL)
Western Blot (1:100-1:250)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells) Lane 2: NBT-II cell lysate (Rat Wistar bladder tumour cells) with PTPN6 polyclonal antibody (Cat # PAB29368) at 1:100-1:250 dilution.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human lymph node with PTPN6 polyclonal antibody (Cat # PAB29368) shows strong cytoplasmic positivity in reaction center cells and lymphoid cells outside reaction centra at 1:200-1:500 dilution.Immunofluorescence
Immunofluorescent staining of human cell line MCF-7 with PTPN6 polyclonal antibody (Cat # PAB29368) at 1-4 ug/mL concentration shows positivity in nucleus and nucleoli. -
Gene Info — PTPN6
Entrez GeneID
5777Gene Name
PTPN6
Gene Alias
HCP, HCPH, HPTP1C, PTP-1C, SH-PTP1, SHP-1, SHP-1L, SHP1
Gene Description
protein tyrosine phosphatase, non-receptor type 6
Omim ID
176883Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq
Other Designations
hematopoietic cell phosphatase|hematopoietic cell protein-tyrosine phosphatase|protein-tyrosine phosphatase 1C
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Interactome
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Pathway
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Disease
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