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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) of human brain, cortex with KCNA3 polyclonal antibody (Cat # PAB27747). Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Entrez GeneID

3738

Protein Accession#

P22001

Gene Name

KCNA3

Gene Alias

HGK5, HLK3, HPCN3, HUKIII, KV1.3, MK3, PCN3

Gene Description

potassium voltage-gated channel, shaker-related subfamily, member 3

Omim ID

176263

Gene Ontology

Hyperlink

Gene Summary

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1. [provided by RefSeq

Other Designations

OTTHUMP00000032397|potassium channel 3|type n potassium channel|voltage-gated potassium channel protein Kv1.3