AKR1A1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of AKR1A1.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human AKR1A1.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Ammonium sulfate precipitation
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:10-50)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of AKR1A1 polyclonal antibody (Cat # PAB2580) in Y-79 cell line lysates (35 ug/lane). AKR1A1 (arrow) was detected using the purified polyclonal antibody.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human hepatocarcinomareacted with AKR1A1 polyclonal antibody (Cat # PAB2580), which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.
This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. -
Gene Info — AKR1A1
Entrez GeneID
10327Protein Accession#
NP_006057;Q6IAZ4Gene Name
AKR1A1
Gene Alias
ALDR1, ALR, ARM, DD3, MGC12529, MGC1380
Gene Description
aldo-keto reductase family 1, member A1 (aldehyde reductase)
Omim ID
103830Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue. Alternative splicing of this gene results in two transcript variants encoding the same protein. [provided by RefSeq
Other Designations
OTTHUMP00000009240|OTTHUMP00000009241|alcohol dehydrogenase|aldehyde reductase|aldo-keto reductase family 1, member A1|dihydrodiol dehydrogenase 3
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Interactome
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Publication Reference
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Interindividual Variability in the Cardiac Expression of Anthracycline Reductases in Donors With and Without Down Syndrome.
Quinones-Lombrana A, Ferguson D, Hageman Blair R, Kalabus JL, Redzematovic A, Blanco JG.
Pharmaceutical Research 2014 Jul; 31(7):1644.
Application:WB, Human, Heart.
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Merging the binding sites of aldose and aldehyde reductase for detection of inhibitor selectivity-determining features.
Steuber H, Heine A, Podjarny A, Klebe G.
Journal of Molecular Biology 2008 Apr; 379(5):991.
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The structure of Apo R268A human aldose reductase: hinges and latches that control the kinetic mechanism.
Bohren KM, Brownlee JM, Milne AC, Gabbay KH, Harrison DH.
Biochimica et Biophysica Acta 2005 May; 1748(2):201.
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Structures of human and porcine aldehyde reductase: an enzyme implicated in diabetic complications.
El-Kabbani O, Green NC, Lin G, Carson M, Narayana SV, Moore KM, Flynn TG, DeLucas LJ.
Acta Crystallographica. Section D, Biological Crystallography 1994 Nov; 50(Pt 6):859.
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Interindividual Variability in the Cardiac Expression of Anthracycline Reductases in Donors With and Without Down Syndrome.
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