BCR (phospho Y177) polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of extract from A-431 ce lls, untreated or treated with EGF (200 ng/mL, 5 min), using BCR (phospho Y177) polyclonal antibody (Cat # PAB25329).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human tonsil tumor tissue, using BCR (phospho Y177) polyclonal antibody (Cat # PAB25329).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of BCR.
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding Y177 of human BCR.
Sequence
P-F-Yp-V-N
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Affinity purification
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (without Mg2+ and Ca2+), 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extract from A-431 ce lls, untreated or treated with EGF (200 ng/mL, 5 min), using BCR (phospho Y177) polyclonal antibody (Cat # PAB25329).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human tonsil tumor tissue, using BCR (phospho Y177) polyclonal antibody (Cat # PAB25329). -
Gene Info — BCR
Entrez GeneID
613Protein Accession#
P11274Gene Name
BCR
Gene Alias
ALL, BCR-ABL1, BCR1, CML, D22S11, D22S662, FLJ16453, PHL
Gene Description
breakpoint cluster region
Gene Ontology
HyperlinkGene Summary
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
bcr-abl1 e14a3 chimeric protein
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Interactome
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Pathway
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Disease
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