KCNQ1 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of KCNQ1.
Immunogen
A synthetic peptide corresponding to C-terminus of human KCNQ1.
Sequence
C-EQLTVPRRGPDEGS
Host
Goat
Theoretical MW (kDa)
61.5, 28
Reactivity
Human
Specificity
This antibody is expected to recognize both reported isoforms (NP_000209.2; NP_861463.1).
Form
Liquid
Purification
Antigen affinity purification
Recommend Usage
ELISA (1:16000)
Immunohistochemistry (6-8 ug/mL)
Western Blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
KCNQ1 polyclonal antibody (Cat # PAB19652) (1 ug/mL) staining of human heart lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
KCNQ1 polyclonal antibody (Cat # PAB19652) (8 ug/mL) staining of paraffin embedded Rat Liver. Heat induced antigen retrieval with citrate buffer Ph 6, HRP-staining.Enzyme-linked Immunoabsorbent Assay
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Gene Info — KCNQ1
Entrez GeneID
3784Protein Accession#
NP_000209.2;NP_861463.1Gene Name
KCNQ1
Gene Alias
ATFB1, FLJ26167, JLNS1, KCNA8, KCNA9, KVLQT1, Kv1.9, Kv7.1, LQT, LQT1, RWS, SQT2, WRS
Gene Description
potassium voltage-gated channel, KQT-like subfamily, member 1
Gene Ontology
HyperlinkGene Summary
This gene encodes a protein for a voltage-gated potassium channel required for the repolarization phase of the cardiac action potential. The gene product can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome, Romano-Ward syndrome, Jervell and Lange-Nielsen syndrome and familial atrial fibrillation. The gene is located in a region of chromosome 11 that contains a large number of contiguous genes that are abnormally imprinted in cancer and the Beckwith-Wiedemann syndrome. Two alternative transcripts encoding distinct isoforms have been described. [provided by RefSeq
Other Designations
Jervell and Lange-Nielsen syndrome 1|kidney and cardiac voltage dependend K+ channel|long (electrocardiographic) QT syndrome, Ward-Romano syndrome 1|slow delayed rectifier channel subunit
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Interactome
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Pathway
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Disease
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