BAX polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic protein of BAX.
Immunogen
Synthetic protein corresponding to human BAX.
Host
Rabbit
Reactivity
Bovine, Human, Mouse, Pig, Rat, Sheep
Form
Lyophilized
Purification
Protein G purification
Recommend Usage
ELISA (1-2 ug/mL)
Western Blot (2-10 ug/mL)
Immunohistochemistry (2-10 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from PBS.
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with deionized water, store at 4°C for one month. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot (Tissue lysate)
Immunohistochemiacl staining of mouse hippocampus with BAX polyclonal antibody (Cat # PAB19559 ).Immunohistochemistry
Immunohistochemiacl staining of mouse hippocampus tissue section with BAX polyclonal antibody (Cat # PAB19559 ) at 1:200 dilution.Enzyme-linked Immunoabsorbent Assay
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Gene Info — BAX
Entrez GeneID
581Protein Accession#
Q07812Gene Name
BAX
Gene Alias
BCL2L4
Gene Description
BCL2-associated X protein
Omim ID
600040Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq
Other Designations
apoptosis regulator BAX
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Interactome
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Pathway
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Disease
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