APOC3 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against recombinant APOC3.
Immunogen
Recombinant protein corresponding to APOC3.
Host
Goat
Reactivity
Human
Specificity
This antibody specifically binds to human APOC3.
Form
Liquid
Recommend Usage
Western Blot (1:2500-1:20000)
ELISA (1:2500-1:20000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (50% glycerol, 0.01% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Enzyme-linked Immunoabsorbent Assay
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Gene Info — APOC3
Entrez GeneID
345Gene Name
APOC3
Gene Alias
APOCIII, MGC150353
Gene Description
apolipoprotein C-III
Omim ID
107720Gene Ontology
HyperlinkGene Summary
Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein. APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia. [provided by RefSeq
Other Designations
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Interactome
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Disease
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Publication Reference
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D25V apolipoprotein C-III variant causes dominant hereditary systemic amyloidosis and confers cardiovascular protective lipoprotein profile.
Valleix S, Verona G, Jourde-Chiche N, Nédelec B, Mangione PP, Bridoux F, Mangé A, Dogan A, Goujon JM, Lhomme M, Dauteuille C, Chabert M, Porcari R, Waudby CA, Relini A, Talmud PJ, Kovrov O, Olivecrona G, Stoppini M, Christodoulou J, Hawkins PN, Grateau G, Delpech M, Kontush A, Gillmore JD, Kalopissis AD, Bellotti V.
Nature Communications 2016 Jan; 7:10353.
Application:IHC-P, IF, WB-Ti, Human, Salivary glands, Digestive tract, Kidney, Plasma.
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D25V apolipoprotein C-III variant causes dominant hereditary systemic amyloidosis and confers cardiovascular protective lipoprotein profile.
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