DARC polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of DARC.
Immunogen
A synthetic peptide corresponding to N-terminus 18 amino acids of human DARC.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of DARC in PC-3 cell lysate with DARC polyclonal antibody (Cat # PAB13255) at (A) 0.5, (B) 1 and (C) 2 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of DARC in human brain tissue with DARC polyclonal antibody (Cat # PAB13255) at 5 ug/mL . -
Gene Info — DARC
Entrez GeneID
2532Protein Accession#
Q16570Gene Name
DARC
Gene Alias
CCBP1, CD234, Dfy, FY, GPD, GpFy, WBCQ1
Gene Description
Duffy blood group, chemokine receptor
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a glycosylated membrane protein and a non-specific receptor for several chemokines. The encoded protein is the receptor for the human malarial parasites Plasmodium vivax and Plasmodium knowlesi. Polymorphisms in this gene are the basis of the Duffy blood group system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
Duffy antigen/chemokine receptor|Duffy blood group antigen|Fy glycoprotein|OTTHUMP00000035293|OTTHUMP00000060081|glycoprotein D
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Interactome
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Disease
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Publication Reference
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The human Duffy antigen binds selected inflammatory but not homeostatic chemokines.
Gardner L, Patterson AM, Ashton BA, Stone MA, Middleton J.
Biochemical and Biophysical Research Communications 2004 Aug; 321(2:306.
Application:Blocking, Human, Human erythrocytes.
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Cloning of glycoprotein D cDNA, which encodes the major subunit of the Duffy blood group system and the receptor for the Plasmodium vivax malaria parasite.
Chaudhuri A, Polyakova J, Zbrzezna V, Williams K, Gulati S, Pogo AO.
PNAS 1993 Nov; 90(22):10793.
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A member of the tetra spans transmembrane protein superfamily is recognized by a monoclonal antibody raised against an HLA class I-deficient, lymphokine-activated killer-susceptible, B lymphocyte line. Cloning and preliminary functional studies.
Gil ML, Vita N, Lebel-Binay S, Miloux B, Chalon P, Kaghad M, Marchiol-Fournigault C, Conjeaud H, Caput D, Ferrara P, et al.
The Journal of Immunology 1992 May; 148(9):2826.
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The human Duffy antigen binds selected inflammatory but not homeostatic chemokines.
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