TNFRSF10B polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of TNFRSF10B.
Immunogen
A synthetic peptide corresponding to C-terminus of human TNFRSF10B.
Host
Rabbit
Reactivity
Human, Mouse
Specificity
This antibody has no cross reaction to DR4.
Form
Liquid
Recommend Usage
Western Blot (1:250-1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for up to one year.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of TNFRSF10B in HeLa (H) and K-562 (K) cell lysates with TNFRSF10B polyclonal antibody (Cat # PAB12830) at 2 ug/mL .Immunocytochemistry
Immunocytochemistry of TNFRSF10B in HeLa cells with TNFRSF10B polyclonal antibody (Cat # PAB12830) at 5 ug/mL . -
Gene Info — TNFRSF10B
Entrez GeneID
8795Protein Accession#
AF012535Gene Name
TNFRSF10B
Gene Alias
CD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9
Gene Description
tumor necrosis factor receptor superfamily, member 10b
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq
Other Designations
Fas-like protein|OTTHUMP00000123492|TNF-related apoptosis-inducing ligand receptor 2|TRAIL receptor 2|apoptosis inducing protein TRICK2A/2B|apoptosis inducing receptor TRAIL-R2|cytotoxic TRAIL receptor-2|death domain containing receptor for TRAIL/Apo-2L|d
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Publication Reference
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Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL.
MacFarlane M, Ahmad M, Srinivasula SM, Fernandes-Alnemri T, Cohen GM, Alnemri ES.
The Journal of Biological Chemistry 1997 Oct; 272(41):25417.
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Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors.
Sheridan JP, Marsters SA, Pitti RM, Gurney A, Skubatch M, Baldwin D, Ramakrishnan L, Gray CL, Baker K, Wood WI, Goddard AD, Godowski P, Ashkenazi A.
Science 1997 Aug; 277(5327):818.
Application:WB-Tr, Human, HEK 293 cells.
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An antagonist decoy receptor and a death domain-containing receptor for TRAIL.
Pan G, Ni J, Wei YF, Yu G, Gentz R, Dixit VM.
Science 1997 Aug; 277(5327):815.
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Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL.
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