BIRC5 (phospho S20) polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of BIRC5.
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding S20 of human BIRC5.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
Western Blot (3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (30% glycerol, 0.09% sodium azide)
Storage Instruction
Store at 4°C for short term. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Recombinant protein)
Western blot detecting phosphorylated recombinant protein (+), but not in unphosphorylated protein (-) with BIRC5 (phospho S20) polyclonal antibody (Cat # PAB12471). -
Gene Info — BIRC5
Entrez GeneID
332Protein Accession#
O15392Gene Name
BIRC5
Gene Alias
API4, EPR-1
Gene Description
baculoviral IAP repeat-containing 5
Omim ID
603352Gene Ontology
HyperlinkGene Summary
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors yet low in adult tissues. Antisense transcripts are involved in the regulation of this gene's expression. At least four transcript variants encoding distinct isoforms have been found for this gene, but the full-length natures of only three of them have been determined. [provided by RefSeq
Other Designations
apoptosis inhibitor 4|baculoviral IAP repeat-containing protein 5|survivin variant 3 alpha
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Interactome
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Pathway
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Disease
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Publication Reference
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Compartmentalized phosphorylation of IAP by protein kinase A regulates cytoprotection.
Dohi T, Xia F, Altieri DC.
Molecular Cell 2007 Jul; 27(1):17.
Application:WB, Human, HeLa, INS-1, MCF-7 cells.
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Compartmentalized phosphorylation of IAP by protein kinase A regulates cytoprotection.
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