CASP3 polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed, paraffin-embedded section of dog ischemic brain stained for Active/Cleaved CASP3 expression. Using CASP3 polyclonal antibody (Cat # PAB0243) at 1 : 2000. Staining is seen in the nuclei of dying neurons (black arrow) but not in the morphologically normal nuclei (open arrows) . CASP3 expression in the nucleus is considered to be a marker of Active/Cleaved CASP3 expression and apoptosis. Hematoxylin-eosin counterstain.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed, paraffin-embedded section of irradiated mouse spleen stained for Active/Cleaved CASP3 expression. Using CASP3 polyclonal antibody (Cat # PAB0243) at 1 : 2000. Staining is seen in the nuclei of a subset of the cell population. CASP3 expression in the nucleus is considered to be a marker of Active/Cleaved CASP3 expression and apoptosis. Hematoxylin-eosin counterstain.
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Specification
Product Description
Rabbit polyclonal antibody raised against full length recombinant CASP3.
Immunogen
Recombinant protein corresponding to full length active human CASP3.
Host
Rabbit
Reactivity
Dog, Gerbils, Human, Mouse, Rat
Form
Liquid
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In serum (0.05% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed, paraffin-embedded section of dog ischemic brain stained for Active/Cleaved CASP3 expression. Using CASP3 polyclonal antibody (Cat # PAB0243) at 1 : 2000. Staining is seen in the nuclei of dying neurons (black arrow) but not in the morphologically normal nuclei (open arrows) . CASP3 expression in the nucleus is considered to be a marker of Active/Cleaved CASP3 expression and apoptosis. Hematoxylin-eosin counterstain.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed, paraffin-embedded section of irradiated mouse spleen stained for Active/Cleaved CASP3 expression. Using CASP3 polyclonal antibody (Cat # PAB0243) at 1 : 2000. Staining is seen in the nuclei of a subset of the cell population. CASP3 expression in the nucleus is considered to be a marker of Active/Cleaved CASP3 expression and apoptosis. Hematoxylin-eosin counterstain.Immunoprecipitation
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Gene Info — CASP3
Entrez GeneID
836Gene Name
CASP3
Gene Alias
CPP32, CPP32B, SCA-1
Gene Description
caspase 3, apoptosis-related cysteine peptidase
Omim ID
600636Gene Ontology
HyperlinkGene Summary
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq
Other Designations
OTTHUMP00000165054|PARP cleavage protease|SREBP cleavage activity 1|Yama|apopain|caspase 3|caspase 3, apoptosis-related cysteine protease|cysteine protease CPP32|procaspase3
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Interactome
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Pathway
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Disease
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