PDGFRB monoclonal antibody, clone 18A2
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Specification
Product Description
Mouse monoclonal antibody raised against full length recombinant PDGFRB.
Immunogen
Recombinant protein corresponding to full length human PDGFRB.
Host
Mouse
Reactivity
Human
Specificity
This antibody is specific to PDGFRB.
Form
Liquid
Isotype
IgG1
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS, pH 7.4 (0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunocytochemistry
Flow Cytometry
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Gene Info — PDGFRB
Entrez GeneID
5159Gene Name
PDGFRB
Gene Alias
CD140B, JTK12, PDGF-R-beta, PDGFR, PDGFR1
Gene Description
platelet-derived growth factor receptor, beta polypeptide
Gene Ontology
HyperlinkGene Summary
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq
Other Designations
beta platelet-derived growth factor receptor|platelet-derived growth factor receptor beta|soluble PDGFRb variant 1
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Interactome
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Pathway
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Disease
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Publication Reference
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Platelet-derived growth factor-receptor alpha strongly inhibits melanoma growth in vitro and in vivo.
Faraone D, Aguzzi MS, Toietta G, Facchiano AM, Facchiano F, Magenta A, Martelli F, Truffa S, Cesareo E, Ribatti D, Capogrossi MC, Facchiano A.
Neoplasia 2009 Aug; 11(8):732.
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The PDGF signaling pathway controls multiple steroid-producing lineages.
Schmahl J, Rizzolo K, Soriano P.
Genes & Development 2008 Dec; 22(23):3255.
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Platelet-derived growth factor receptors direct vascular development independent of vascular smooth muscle cell function.
French WJ, Creemers EE, Tallquist MD.
Molecular and Cellular Biology 2008 Sep; 28(18):5646.
Application:IHC-Fr, WB-Ti, Mouse, Mouse embryo.
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Role of platelet-derived growth factors in physiology and medicine.
Andrae J, Gallini R, Betsholtz C.
Genes & Development 2008 May; 22(10):1276.
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Platelet-derived growth factor-receptor alpha strongly inhibits melanoma growth in vitro and in vivo.
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