MME monoclonal antibody, clone SN5c/L4-1A1
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Specification
Product Description
Mouse monoclonal antibody raised against native MME.
Immunogen
Native purified MME from membrane preparation of human B-lineage leukemia cells.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG1, kappa
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In 50 mM sodium phosphate buffer, 100 mM potassium Chloride, 150 mM NaCl, pH 7.5 (0.5 mg/mL gentamicin sulfate)
Storage Instruction
Store at 4°C.
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Applications
Immunohistochemistry (Frozen sections)
Immunoprecipitation
Flow Cytometry
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Gene Info — MME
Entrez GeneID
4311Gene Name
MME
Gene Alias
CALLA, CD10, DKFZp686O16152, MGC126681, MGC126707, NEP
Gene Description
membrane metallo-endopeptidase
Omim ID
120520Gene Ontology
HyperlinkGene Summary
This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing. [provided by RefSeq
Other Designations
atriopeptidase|common acute lymphocytic leukemia antigen|enkephalinase|membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase)|membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10)|membrane metallo-endopeptidase
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Interactome
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Pathway
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Disease
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Publication Reference
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In vitro and in vivo cytotoxic activity of anti-human leukemia monoclonal antibodies SN5c and SN6 daunorubicin conjugates.
Biddle WC, Haruta Y, Seon BK, Henderson ES, Sarcione EJ.
Leukemia Research 1989 Jan; 13(8):699.
Application:ELISA, Flow Cyt, Func, Human, BALL-1 cells, CCRF-SB cells, KM-3 cells, MOLT-4 cells, NALM-6 cells, HL-60 cells, Human bone marrow cells, Human PBMCs.
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Efficient transplantation of human non-T-leukemia cells into nude mice and induction of complete regression of the transplanted distinct tumors by ricin A-chain conjugates of monoclonal antibodies SN5 and SN6.
Hara H, Luo Y, Haruta Y, Seon BK.
Cancer Research 1988 Aug; 48(16):4673.
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Unique epitopes of common acute lymphoblastic leukemia antigen detected by new monoclonal antibodies.
Matsuzaki H, Haruta Y, Fukukawa T, Barcos MP, Seon BK.
Cancer Research 1989 Apr; 47(8):2160.
Application:C-ELISA, RIA, Human, NALM-6 cells, Human malignant cells.
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In vitro and in vivo cytotoxic activity of anti-human leukemia monoclonal antibodies SN5c and SN6 daunorubicin conjugates.
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