CD70 monoclonal antibody, clone BU69
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against native CD70.
Immunogen
Native purified CD70 from human WM-1 (Waldenstrom's macroglobulinemia) cell line.
Host
Mouse
Theoretical MW (kDa)
30
Reactivity
Human
Specificity
This antibody recognizes CD70.
Form
Liquid
Isotype
IgG1
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In 50 mM sodium phosphate buffer, 100 mM potassium Chloride, 150 mM NaCl, pH 7.5 (0.5 mg/mL gentamicin sulfate)
Storage Instruction
Store at 4°C.
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Applications
Immunohistochemistry (Frozen sections)
Immunoprecipitation
Flow Cytometry
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Gene Info — CD70
Entrez GeneID
970Gene Name
CD70
Gene Alias
CD27L, CD27LG, TNFSF7
Gene Description
CD70 molecule
Omim ID
602840Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq
Other Designations
CD27 ligand|CD70 antigen|Ki-24 antigen|surface antigen CD70|tumor necrosis factor (ligand) superfamily, member 7|tumor necrosis factor ligand superfamily, member 7
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Interactome
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Pathway
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Disease
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Publication Reference
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Soluble CD27 induces IgG production through activation of antigen-primed B cells.
Dang LV, Nilsson A, Ingelman-Sundberg H, Cagigi A, Gelinck LB, Titanji K, De Milito A, Grutzmeier S, Hedlund J, Kroon FP, Chiodi F.
Journal of Internal Medicine 2012 Mar; 271(3):282.
Application:Flow Cyt, Human, PBMCs.
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Lipopolysaccharide stimulation converts vigorously washed dendritic cells (DCs) to nonexhausted DCs expressing CD70 and evoking long-lasting type 1 T cell responses.
Iwamoto S, Ishida M, Takahashi K, Takeda K, Miyazaki A.
Journal of Leukocyte Biology 2005 Aug; 78(2):383.
Application:Flow Cyt, Human, Dendritic cells (DCs).
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Identification of CD70-mediated apoptosis of immune effector cells as a novel immune escape pathway of human glioblastoma.
Wischhusen J, Jung G, Radovanovic I, Beier C, Steinbach JP, Rimner A, Huang H, Schulz JB, Ohgaki H, Aguzzi A, Rammensee HG, Weller M.
Cancer Research 2002 May; 62(9):2592.
Application:Flow Cyt, IHC, WB-Ce, Human, LN-18, U138-MG, U87MG, LN-428, D247MG, T98G, LN-319, LN-229, A172, U251MG, U373MG, LN-308, Glioma cells.
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Direct cellular communications between CD45R0 and CD45RA T cell subsets via CD27/CD70.
Agematsu K, Kobata T, Sugita K, Hirose T, Schlossman SF, Morimoto C.
The Journal of Immunology 1995 Apr; 154(8):3627.
Application:IF, Human, CD45RA+/CD45RO+ CD4 T cells.
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Soluble CD27 induces IgG production through activation of antigen-primed B cells.
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