CD40 monoclonal antibody, clone BE-1
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Specification
Product Description
Mouse monoclonal antibody raised against native CD40.
Immunogen
Native purified CD40 from murine L cells.
Host
Mouse
Reactivity
Human
Specificity
This antibody binds with cross linked BE-1 will partially activate B cells.
Form
Liquid
Isotype
IgG1
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In 50 mM sodium phosphate buffer, 100 mM potassium Chloride, 150 mM NaCl, pH 7.5 (0.5 mg/mL gentamicin sulfate)
Storage Instruction
Store at 4°C.
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Applications
Immunohistochemistry (Frozen sections)
Immunoprecipitation
Flow Cytometry
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Gene Info — CD40
Entrez GeneID
958Gene Name
CD40
Gene Alias
Bp50, CDW40, MGC9013, TNFRSF5, p50
Gene Description
CD40 molecule, TNF receptor superfamily member 5
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq
Other Designations
B cell surface antigen CD40|B cell-associated molecule|CD40 antigen|CD40 antigen (TNF receptor superfamily member 5)|CD40 type II isoform|CD40L receptor|OTTHUMP00000031699|OTTHUMP00000031700|nerve growth factor receptor-related B-lymphocyte activation mol
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Interactome
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Pathway
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Disease
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Publication Reference
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Assembly and regulation of the CD40 receptor complex in human B cells.
Kuhne MR, Robbins M, Hambor JE, Mackey MF, Kosaka Y, Nishimura T, Gigley JP, Noelle RJ, Calderhead DM.
The Journal of Experimental Medicine 1997 Jul; 186(2):337.
Application:IP, Human, DND39 cells, Human B cells.
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Immune regulation by CD40 and its ligand GP39.
Foy TM, Aruffo A, Bajorath J, Buhlmann JE, Noelle RJ.
Annual Review of Immunology 1996 Apr; 14:591.
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Analysis of expression and function of CD40 on normal and leukemic human B cell precursors.
Law CL, Wormann B, LeBien TW.
Leukemia 1990 Nov; 4(11):732.
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Assembly and regulation of the CD40 receptor complex in human B cells.
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