MMP3 monoclonal antibody, clone SB14d
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Paraffin embedded sections of human colon carcinoma were stained with MMP3 monoclonal antibody, clone SB14d (Cat # MAB3331). Goat Anti-Mouse IgG2a, human ads-BIOT and Streptavidin-HRP were used and then developed with DAB.
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Specification
Product Description
Mouse monoclonal antibody raised against recombinant MMP3.
Immunogen
Recombinant protein corresponding to human MMP3.
Host
Mouse
Reactivity
Human
Specificity
human MMP-3, Does not cross react to human MMP-1, MMP-2 or MMP-9.
Form
Liquid
Isotype
IgG2a
Recommend Usage
ELISA (1:3000-1:8000)
Immunohistochemistry (2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 100 mM BBS, pH 8.2
Storage Instruction
Store at 4°C.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Paraffin embedded sections of human colon carcinoma were stained with MMP3 monoclonal antibody, clone SB14d (Cat # MAB3331). Goat Anti-Mouse IgG2a, human ads-BIOT and Streptavidin-HRP were used and then developed with DAB.Immunohistochemistry (Frozen sections)
Enzyme-linked Immunoabsorbent Assay
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Gene Info — MMP3
Entrez GeneID
4314Gene Name
MMP3
Gene Alias
CHDS6, MGC126102, MGC126103, MGC126104, MMP-3, SL-1, STMY, STMY1, STR1
Gene Description
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
Omim ID
185250Gene Ontology
HyperlinkGene Summary
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq
Other Designations
matrix metalloproteinase 3|matrix metalloproteinase 3 (stromelysin 1, progelatinase)|progelatinase|proteoglycanase|stromelysin 1|transin-1
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Interactome
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Disease
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Publication Reference
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Generation of an angiostatin-like fragment from plasminogen by stromelysin-1 (MMP-3).
Lijnen HR, Ugwu F, Bini A, Collen D.
Biochemistry 1998 Apr; 37(14):4699.
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Degradation of cross-linked fibrin by matrix metalloproteinase 3 (stromelysin 1): hydrolysis of the gamma Gly 404-Ala 405 peptide bond.
Bini A, Itoh Y, Kudryk BJ, Nagase H.
Biochemistry 1996 Oct; 35(40):13056.
Application：Func, WB-Re, Recombinant protein.
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Biochemical characterization of human collagenase-3.
Knäuper V, López-Otin C, Smith B, Knight G, Murphy G.
The Journal of Biological Chemistry 1996 Jan; 271(3):1544.
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Generation of an angiostatin-like fragment from plasminogen by stromelysin-1 (MMP-3).
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