CSF2 monoclonal antibody, clone BVD2-21C11
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Specification
Product Description
Rat monoclonal antibody raised against recombinant CSF2.
Immunogen
Recombinant protein corresponding to human CSF2.
Host
Rat
Reactivity
Human, Macaque
Specificity
human granulocyte/macrophage colony stimulating factor (GM-CSF) The BVD2-21C11 antibody has been reported to cross react with GM-CSF from Rhesus monkey. This is a neutralizing antibody.
Form
Liquid
Isotype
IgG2a
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In 100 mM BBS, pH 8.2
Storage Instruction
Store at 4°C.
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Applications
Immunofluorescence
Flow Cytometry
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Gene Info — CSF2
Entrez GeneID
1437Gene Name
CSF2
Gene Alias
GMCSF, MGC131935, MGC138897
Gene Description
colony stimulating factor 2 (granulocyte-macrophage)
Omim ID
138960Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. [provided by RefSeq
Other Designations
colony stimulating factor 2|granulocyte-macrophage colony stimulating factor|molgramostin|sargramostim
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Interactome
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Pathway
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Disease
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Publication Reference
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Strategies of anti-cytokine monoclonal antibody development: immunoassay of IL-10 and IL-5 in clinical samples.
Abrams JS, Roncarolo MG, Yssel H, Andersson U, Gleich GJ, Silver JE.
Immunological Reviews 2006 Jun; 127:5.
Application:Blocking, Det Ab, ELISA, IP, Human, Supernatants from cells cultured and stimulated ex vivo with different agents and biological fluids like sera/plasma, bronehoalveolar lavage, ascites, urines, cerebrospinal fluids, saliva, and sputa. .
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Granulocyte/macrophage colony-stimulating factor and interleukin 3 release from human peripheral blood eosinophils and neutrophils.
Kita H, Ohnishi T, Okubo Y, Weiler D, Abrams JS, Gleich GJ.
The Journal of Experimental Medicine 1991 Sep; 174(3):745.
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Host-reactive CD4+ and CD8+ T cell clones isolated from a human chimera produce IL-5, IL-2, IFN-gamma and granulocyte/macrophage-colony-stimulating factor but not IL-4.
Bacchetta R, de Waal Malefijt R, Yssel H, Abrams J, de Vries JE, Spits H, Roncarolo MG.
The Journal of Immunology 1990 Feb; 144(3):902.
Application:EIA, Human, T cell clones supernatants.
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Strategies of anti-cytokine monoclonal antibody development: immunoassay of IL-10 and IL-5 in clinical samples.
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