IL10 monoclonal antibody, clone JES3-12G8
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Specification
Product Description
Rat monoclonal antibody raised against IL10.
Immunogen
Human IL10.
Host
Rat
Reactivity
Human
Specificity
human IL-10.
Form
Liquid
Isotype
IgG2a
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In 100 mM BBS, pH 8.2
Storage Instruction
Store at 4°C.
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Applications
Western Blot
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Gene Info — IL10
Entrez GeneID
3586Gene Name
IL10
Gene Alias
CSIF, IL-10, IL10A, MGC126450, MGC126451, TGIF
Gene Description
interleukin 10
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. [provided by RefSeq
Other Designations
cytokine synthesis inhibitory factor
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Interactome
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Pathway
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Disease
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Publication Reference
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Epstein-Barr virus transformation induces B lymphocytes to produce human interleukin 10.
Burdin N, Peronne C, Banchereau J, Rousset F.
The Journal of Experimental Medicine 1993 Feb; 177(2):295.
Application:ELISA, Human, Burkitt lymphoma cell line Jijoye, Human B cell lines, .
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IL-10 is produced by subsets of human CD4+ T cell clones and peripheral blood T cells.
Yssel H, De Waal Malefyt R, Roncarolo MG, Abrams JS, Lahesmaa R, Spits H, de Vries JE.
The Journal of Immunology 1992 Oct; 149(7):2378.
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Strategies of anti-cytokine monoclonal antibody development: immunoassay of IL-10 and IL-5 in clinical samples.
Abrams JS, Roncarolo MG, Yssel H, Andersson U, Gleich GJ, Silver JE.
Immunological Reviews 2006 Jun; 127:5.
Application:Blocking, Det Ab, ELISA, Human, Supernatants from cells cultured and stimulated ex vivo with different agents and biological fluids like sera/plasma, bronehoalveolar lavage, ascites, urines, cerebrospinal fluids, saliva, and sputa. .
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Epstein-Barr virus transformation induces B lymphocytes to produce human interleukin 10.
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