HNRNPK monoclonal antibody, clone 3C2
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Specification
Product Description
Mouse monoclonal antibody raised against HNRNPK.
Immunogen
Human HNRNPK.
Host
Mouse
Theoretical MW (kDa)
65
Reactivity
Bovine, Clawed frog, Hamster, Human, Rat
Specificity
Detects a band of approximately 65 KDa.
Form
Liquid
Isotype
IgG2b
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot for HNRNPK monoclonal antibody, clone 3C2 (Cat # MAB2478) on HeLa cell extracts.Immunofluorescence
Immunoprecipitation
Enzyme-linked Immunoabsorbent Assay
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Gene Info — HNRNPK
Entrez GeneID
3190Gene Name
HNRNPK
Gene Alias
CSBP, FLJ41122, HNRPK, TUNP
Gene Description
heterogeneous nuclear ribonucleoprotein K
Omim ID
600712Gene Ontology
HyperlinkGene Summary
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene is located in the nucleoplasm and has three repeats of KH domains that binds to RNAs. It is distinct among other hnRNP proteins in its binding preference; it binds tenaciously to poly(C). This protein is also thought to have a role during cell cycle progession. Several alternatively spliced transcript variants have been described for this gene, however, not all of them are fully characterized. [provided by RefSeq
Other Designations
OTTHUMP00000021554|OTTHUMP00000021557|OTTHUMP00000021558|dC-stretch binding protein|transformation upregulated nuclear protein
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Interactome
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Publication Reference
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Involvement of Hu and heterogeneous nuclear ribonucleoprotein K in neuronal differentiation through p21 mRNA post-transcriptional regulation.
Yano M, Okano HJ, Okano H.
The Journal of Biological Chemistry 2005 Apr; 280(13):12690.
Application:WB-Ce, WB-Ti, Human, 293T, PC12 cells.
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Characterization and primary structure of the poly(C)-binding heterogeneous nuclear ribonucleoprotein complex K protein.
Matunis MJ, Michael WM, Dreyfuss G.
Molecular and Cellular Biology 1992 Jan; 12(1):164.
Application:IF, IP, WB-Re, WB-Ti, Bovine, Hamster, Human, HeLa cells, Kidney, Purified proteins.
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Involvement of Hu and heterogeneous nuclear ribonucleoprotein K in neuronal differentiation through p21 mRNA post-transcriptional regulation.
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