CASP3 monoclonal antibody, clone AM1-4
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
-
Specification
Product Description
Mouse monoclonal antibody raised against recombinant CASP3.
Immunogen
Recombinant protein corresponding to human CASP3.
Host
Mouse
Reactivity
Human
Form
Liquid
Purification
Protein A/G chromatography
Isotype
IgG
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Recommend Usage
Western Blot
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.08% sodium azide).
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Western Blot
-
Gene Info — CASP3
Entrez GeneID
836Protein Accession#
P42574Gene Name
CASP3
Gene Alias
CPP32, CPP32B, SCA-1
Gene Description
caspase 3, apoptosis-related cysteine peptidase
Omim ID
600636Gene Ontology
HyperlinkGene Summary
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq
Other Designations
OTTHUMP00000165054|PARP cleavage protease|SREBP cleavage activity 1|Yama|apopain|caspase 3|caspase 3, apoptosis-related cysteine protease|cysteine protease CPP32|procaspase3
-
Interactome
-
Pathway
-
Disease
-
Publication Reference
-
Presence of a pre-apoptotic complex of pro-caspase-3, Hsp60 and Hsp10 in the mitochondrial fraction of jurkat cells.
Samali A, Cai J, Zhivotovsky B, Jones DP, Orrenius S.
The EMBO Journal 1999 Apr; 18(8):2040.
Application:WB-Ce, Human, Jurkat cells.
-
Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner.
Slee EA, Harte MT, Kluck RM, Wolf BB, Casiano CA, Newmeyer DD, Wang HG, Reed JC, Nicholson DW, Alnemri ES, Green DR, Martin SJ.
The Journal of Cell Biology 1999 Jan; 144(2):281.
Application:WB-Ce, Human, Jurkat cells.
-
Redox regulation of caspase-3(-like) protease activity: regulatory roles of thioredoxin and cytochrome c.
Ueda S, Nakamura H, Masutani H, Sasada T, Yonehara S, Takabayashi A, Yamaoka Y, Yodoi J.
The Journal of Immunology 1998 Dec; 161(12):6689.
Application:WB-Ce, Human, Jurkat cells.
-
Presence of a pre-apoptotic complex of pro-caspase-3, Hsp60 and Hsp10 in the mitochondrial fraction of jurkat cells.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com