CDH2 monoclonal antibody, clone M170
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot of human endothelial cells untreated (lane 1) or treated with pervanadate (1 mM) for 30 min (lane 2). The blots were probed with CDH2 monoclonal antibody, clone M170 (Cat # MAB1381).
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant CDH2.
Immunogen
Recombinant protein corresponding to C-terminus of human CDH2.
Host
Mouse
Reactivity
Human, Mouse, Rat
Specificity
This sequence is highly conserved in rat and mouse N-Cadherin, and has some homology to R-cadherin.
Form
Liquid
Isotype
IgG1
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Recommend Usage
ELISA (1:2000)
Immunocytochemistry (1:200)
Immunoprecipitation (1:100)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (50% glycerol, 1 mg/mL BSA, 0.05% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot of human endothelial cells untreated (lane 1) or treated with pervanadate (1 mM) for 30 min (lane 2). The blots were probed with CDH2 monoclonal antibody, clone M170 (Cat # MAB1381).Immunocytochemistry
Immunoprecipitation
Enzyme-linked Immunoabsorbent Assay
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Gene Info — CDH2
Entrez GeneID
1000Protein Accession#
P19022Gene Name
CDH2
Gene Alias
CD325, CDHN, CDw325, NCAD
Gene Description
cadherin 2, type 1, N-cadherin (neuronal)
Omim ID
114020Gene Ontology
HyperlinkGene Summary
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product. [provided by RefSeq
Other Designations
N-cadherin 1|cadherin 2, N-cadherin (neuronal)|cadherin 2, type 1|calcium-dependent adhesion protein, neuronal|neural cadherin
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Interactome
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Pathway
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Disease
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Publication Reference
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Involvement of Src family kinases in N-cadherin phosphorylation and beta-catenin dissociation during transendothelial migration of melanoma cells.
Qi J, Wang J, Romanyuk O, Siu CH.
Molecular Biology of the Cell 2005 Dec; 17(3):1261.
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Identification of cadherin tyrosine residues that are phosphorylated and mediate Shc association.
Xu Y, Carpenter G.
Journal of Cellular Biochemistry 1999 Nov; 75(2):264.
Application：WB-Re, Recombinant proteins.
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Interaction of the adaptor protein Shc and the adhesion molecule cadherin.
Xu Y, Guo DF, Davidson M, Inagami T, Carpenter G.
The Journal of Biological Chemistry 1997 May; 272(21):13463.
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Involvement of Src family kinases in N-cadherin phosphorylation and beta-catenin dissociation during transendothelial migration of melanoma cells.
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