BIRC5 (Human) ELISA Kit
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Specifications
Product Description
BIRC5 (Human) ELISA Kit is a sandwich enzyme immunoassay for the quantitative measurement of human BIRC5.
Suitable Sample
Cell Culture Supernatant, Cell Lysates, Plasma (EDTA, Heparin), Serum
Sample Volume
100 uL
Label
HRP-conjugated
Detection Method
Colorimetric
Assay Type
Quantitative
Calibration Range
62.5 to 4000 pg/mL
Reactivity
Human
Regulation Status
For research use only (RUO)
Storage Instruction
Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles.
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Applications
Quantification
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Gene Info — BIRC5
Entrez GeneID
332Gene Name
BIRC5
Gene Alias
API4, EPR-1
Gene Description
baculoviral IAP repeat-containing 5
Omim ID
603352Gene Ontology
HyperlinkGene Summary
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors yet low in adult tissues. Antisense transcripts are involved in the regulation of this gene's expression. At least four transcript variants encoding distinct isoforms have been found for this gene, but the full-length natures of only three of them have been determined. [provided by RefSeq
Other Designations
apoptosis inhibitor 4|baculoviral IAP repeat-containing protein 5|survivin variant 3 alpha
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Interactomes
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Pathways
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Diseases
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Publication Reference
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Detection of survivin expression in bladder cancer and renal cell carcinoma using specific monoclonal antibodies.
Chen D, Xu J, Zhang Q.
Oncology Reports 2018 Jun; 39(6):2817.
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Survivin is not a promising serological maker for the diagnosis of hepatocellular carcinoma.
Jia X, Gao Y, Zhai D, Liu J, Wang Y, Jing LI, DU Z.
Oncology Letters 2015 May; 9(5):2347.
Application:ELISA, Human, Serum.
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Inhibitor of apoptosis protein survivin regulates vascular injury.
Blanc-Brude OP, Yu J, Simosa H, Conte MS, Sessa WC, Altieri DC.
Nature Medicine 2002 Sep; 8(9):987.
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Control of apoptosis and mitotic spindle checkpoint by survivin.
Li F, Ambrosini G, Chu EY, Plescia J, Tognin S, Marchisio PC, Altieri DC.
Nature 1998 Dec; 396(6711):580.
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A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma.
Ambrosini G, Adida C, Altieri DC.
Nature Medicine 1997 Aug; 3(8):917.
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Detection of survivin expression in bladder cancer and renal cell carcinoma using specific monoclonal antibodies.
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