CDH1 (Human) ELISA Kit
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Specification
Product Description
CDH1 (Human) ELISA Kit is a sandwich enzyme immunoassay for the quantitative measurement of human CDH1.
Suitable Sample
Cell Culture Supernatant, Plasma (Heparin), Serum, Saliva, Urine
Sample Volume
100 uL
Label
HRP-conjugated
Detection Method
Colorimetric
Assay Type
Quantitative
Calibration Range
156 to 10000 pg/mL
Reactivity
Human
Regulation Status
For research use only (RUO)
Quality Control Testing
Standard curve
The standard curve is for the purpose of illustration only and should not be used to calculate unknowns. A standard curve should be generated each time the assay is performed.
Storage Instruction
Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles.
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Applications
Quantification
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Gene Info — CDH1
Entrez GeneID
999Gene Name
CDH1
Gene Alias
Arc-1, CD324, CDHE, ECAD, LCAM, UVO
Gene Description
cadherin 1, type 1, E-cadherin (epithelial)
Gene Ontology
HyperlinkGene Summary
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq
Other Designations
cadherin 1, E-cadherin (epithelial)|cadherin 1, type 1|calcium-dependent adhesion protein, epithelial|cell-CAM 120/80|uvomorulin
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Interactome
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Pathway
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Disease
- Adenocarcinoma
- Asthma
- Breast cancer
- Breast Neoplasms
- Bronchiolitis
- Carcinoma
- Cleft Lip
- Cleft Palate
- Colitis
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Publication Reference
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Tripterygium glycoside suppresses epithelial-to-mesenchymal transition of diabetic kidney disease podocytes by targeting autophagy through the mTOR/Twist1 pathway.
Mei Tao, Danna Zheng, Xudong Liang, Diandian Wu, Kang Hu, Juan Jin, Qiang He.
Molecular MedicineRreports 2021 Aug; 24(2):592.
Application:Quant, Human, Human serum.
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The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells.
Batlle E, Sancho E, Franci C, Dominguez D, Monfar M, Baulida J, Garcia De Herreros A.
Nature Cell Biology 2000 Feb; 2(2):84.
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Cloning and characterization of the human invasion suppressor gene E-cadherin (CDH1).
Berx G, Staes K, van Hengel J, Molemans F, Bussemakers MJ, van Bokhoven A, van Roy F.
Genomics 1995 Mar; 26(2):281.
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E-cadherin gene mutations provide clues to diffuse type gastric carcinomas.
Becker KF, Atkinson MJ, Reich U, Becker I, Nekarda H, Siewert JR, Hofler H.
Cancer Research 1994 Jul; 54(14):3845.
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Tripterygium glycoside suppresses epithelial-to-mesenchymal transition of diabetic kidney disease podocytes by targeting autophagy through the mTOR/Twist1 pathway.
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