AKR1A1 (Human) Recombinant Protein (P01)
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
-
Specification
Product Description
Human AKR1A1 full-length ORF ( AAH00670, 1 a.a. - 325 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MAASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIVPMLTVDGKRVPRDAGHPLYPFNDPY
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
61.49
Interspecies Antigen Sequence
Mouse (93); Rat (94)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
-
Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
-
Gene Info — AKR1A1
Entrez GeneID
10327GeneBank Accession#
BC000670Protein Accession#
AAH00670Gene Name
AKR1A1
Gene Alias
ALDR1, ALR, ARM, DD3, MGC12529, MGC1380
Gene Description
aldo-keto reductase family 1, member A1 (aldehyde reductase)
Omim ID
103830Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue. Alternative splicing of this gene results in two transcript variants encoding the same protein. [provided by RefSeq
Other Designations
OTTHUMP00000009240|OTTHUMP00000009241|alcohol dehydrogenase|aldehyde reductase|aldo-keto reductase family 1, member A1|dihydrodiol dehydrogenase 3
-
Interactome
-
Pathway
-
Disease
-
Publication Reference
-
In vitro metabolism of a novel JNK inhibitor tanzisertib: interspecies differences in oxido-reduction and characterization of enzymes involved in metabolism.
Atsriku C, Hoffmann M, Moghaddam M, Kumar G, Surapaneni S.
Xenobiotica 2015 Jun; 45(6):465.
Application：Enzyme, Human, Tanzisertib were incubated in human liver microsomes, cytosol and hepatocytes.
-
CBR1 is a predominant doxorubicin reductase in the human liver.
Kassner N, Huse K, Martin HJ, Godtel-Armbrust U, Metzger A, Meineke I, Brockmoller J, Klein K, Zanger UM, Maser E, Wojnowski L.
Drug Metabolism and Disposition 2008 Jul; 36(10):2113.
Application：Enzyme, Doxorubicin.
-
In vitro metabolism of a novel JNK inhibitor tanzisertib: interspecies differences in oxido-reduction and characterization of enzymes involved in metabolism.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com