ARTN (Human) Recombinant Protein (P01)
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More Files
- More Functions
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Specification
Product Description
Human ARTN full-length ORF ( AAH62375.1, 1 a.a. - 228 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MELGLGGLSTLSHCPWPRQQAPLGLSAQPALWPTLAALALLSSVAEASLGSAPRSPAPREGPPPVLASPAGHLPGGRTARWCSGRARRPPPQPSRPAPPPPAPPSALPRGGRAARAGGPGSRARAAGARGCRLRSQLVPVRALGLGHRSDELVRFRFCSGSCRRARSPHDLSLASLLGAGALRPPPGSRPVSQPCCRPTRYEAVSFMDVNSTWRTVDRLSATACGCLG
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
50
Interspecies Antigen Sequence
Mouse (73); Rat (75)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — ARTN
Entrez GeneID
9048GeneBank Accession#
BC062375.1Protein Accession#
AAH62375.1Gene Name
ARTN
Gene Alias
ENOVIN, EVN, NBN
Gene Description
artemin
Omim ID
603886Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the glial cell line-derived neurotophic factor (GDNF) family of ligands which are a group of ligands within the TGF-beta superfamily of signaling molecules. GDNFs are unique in having neurotrophic properties and have potential use for gene therapy in neurodegenerative disease. Artemin has been shown in culture to support the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. Its role in the PNS and CNS is further substantiated by its expression pattern in the proximity of these neurons. This protein is a ligand for the RET receptor and uses GFR-alpha 3 as a coreceptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000009173|OTTHUMP00000009174|neublastin|neurotrophic factor|neurotrophic factor artemin
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Disease
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