FADD 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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SDS-PAGE Gel
FADD transfected lysate.
Western Blot
Lane 1: FADD transfected lysate ( 22.99 KDa)
Lane 2: Non-transfected lysate.
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-FADD full-length
Host
Human
Theoretical MW (kDa)
23.3
Interspecies Antigen Sequence
Mouse (68); Rat (68)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-FADD antibody (H00008772-D01P) by Western Blots.
SDS-PAGE Gel
FADD transfected lysate.
Western Blot
Lane 1: FADD transfected lysate ( 22.99 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — FADD
Entrez GeneID
8772GeneBank Accession#
NM_003824Protein Accession#
NP_003815.1Gene Name
FADD
Gene Alias
GIG3, MGC8528, MORT1
Gene Description
Fas (TNFRSF6)-associated via death domain
Omim ID
602457Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq
Other Designations
Fas-associated via death domain|Fas-associating death domain-containing protein|Fas-associating protein with death domain|growth-inhibiting gene 3 protein|mediator of receptor-induced toxicity
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Interactome
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Pathway
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Disease
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