RAD1 (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human RAD1 full-length ORF ( NP_002844.1, 1 a.a. - 282 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MPLLTQQIQDEDDQYSLVASLDNVRNLSTILKAIHFREHATCFATKNGIKVTVENAKCVQANAFIQAGIFQEFKVQEESVTFRINLTVLLDCLSIFGSSPMPGTLTALRMCYQGYGYPLMLFLEEGGVVTVCKINTQEPEETLDFDFCSTNVINKIILQSEGLREAFSELDMTSEVLQITMSPDKPYFRLSTFGNAGSSHLDYPKDSDLMEAFHCNQTQVNRYKISLLKPSTKALVLSCKVSIRTDNRGFLSLQYMIRNEDGQICFVEYYCCPDEEVPESES
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
58.2
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — RAD1
Entrez GeneID
5810GeneBank Accession#
NM_002853.3Protein Accession#
NP_002844.1Gene Name
RAD1
Gene Alias
HRAD1, REC1
Gene Description
RAD1 homolog (S. pombe)
Omim ID
603153Gene Ontology
HyperlinkGene Summary
This gene encodes a component of a heterotrimeric cell cycle checkpoint complex, known as the 9-1-1 complex, that is activated to stop cell cycle progression in response to DNA damage or incomplete DNA replication. The 9-1-1 complex is recruited by RAD17 to affected sites where it may attract specialized DNA polymerases and other DNA repair effectors. Alternatively spliced transcript variants of this gene have been described. [provided by RefSeq
Other Designations
DNA repair exonuclease REC1|OTTHUMP00000115992|RAD1 homolog|Rad1-like DNA damage checkpoint|cell cycle checkpoint protein Hrad1|checkpoint control protein HRAD1|exonuclease homolog RAD1
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Interactome
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Disease
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