Products

Immunoprecipitation-Western Blot

Entrez GeneID

Gene Name

MDM4

Gene Alias

DKFZp781B1423, HDMX, MDMX, MGC132766, MRP1

Gene Description

Mdm4 p53 binding protein homolog (mouse)

Omim ID

Gene Ontology

Gene Summary

The human MDM4 gene, which plays a role in apoptosis, encodes a 490-amino acid protein containing a RING finger domain and a putative nuclear localization signal. The MDM4 putative nuclear localization signal, which all Mdm proteins contain, is located in the C-terminal region of the protein. The mRNA is expressed at a high level in thymus and at lower levels in all other tissues tested. MDM4 protein produced by in vitro translation interacts with p53 via a binding domain located in the N-terminal region of the MDM4 protein. MDM4 shows significant structural similarity to p53-binding protein MDM2. Two transcript variants, one protein-coding and the other likely not to be protein-coding, have been found for this gene. [provided by RefSeq

Other Designations

MDM4-related protein 1|Mdm4, transformed 3T3 cell double minute 4, p53 binding protein|double minute 4, human homolog of; p53-binding protein|mouse double minute 4 homolog|p53-binding protein