MDM4 MaxPab rabbit polyclonal antibody (D01)
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human MDM4 protein.
Immunogen
MDM4 (NP_002384.2, 1 a.a. ~ 490 a.a) full-length human protein.
Sequence
MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTLALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQDETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWFLNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQLVIKVFIA
Host
Rabbit
Reactivity
Human, Mouse, Rat
Interspecies Antigen Sequence
Mouse (84); Rat (84)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
No additive
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Tissue lysate)
MDM4 MaxPab rabbit polyclonal antibody. Western Blot analysis of MDM4 expression in human stomach.Western Blot (Tissue lysate)
MDM4 MaxPab rabbit polyclonal antibody. Western Blot analysis of MDM4 expression in mouse testis.Western Blot (Cell lysate)
MDM4 MaxPab rabbit polyclonal antibody. Western Blot analysis of MDM4 expression in MCF-7.Western Blot (Cell lysate)
MDM4 MaxPab rabbit polyclonal antibody. Western Blot analysis of MDM4 expression in PC-12.Western Blot (Transfected lysate)
Western Blot analysis of MDM4 expression in transfected 293T cell line (H00004194-T02) by MDM4 MaxPab polyclonal antibody.
Lane 1: MDM4 transfected lysate(54.90 KDa).
Lane 2: Non-transfected lysate.
Immunoprecipitation
Immunoprecipitation of MDM4 transfected lysate using anti-MDM4 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead, and immunoblotted with MDM4 purified MaxPab mouse polyclonal antibody (B01P) (H00004194-B01P).Immunofluorescence
Immunofluorescence of purified MaxPab antibody to MDM4 on HeLa cell. [antibody concentration 10 ug/ml] -
Gene Info — MDM4
Entrez GeneID
4194GeneBank Accession#
NM_002393Protein Accession#
NP_002384.2Gene Name
MDM4
Gene Alias
DKFZp781B1423, HDMX, MDMX, MGC132766, MRP1
Gene Description
Mdm4 p53 binding protein homolog (mouse)
Omim ID
602704Gene Ontology
HyperlinkGene Summary
The human MDM4 gene, which plays a role in apoptosis, encodes a 490-amino acid protein containing a RING finger domain and a putative nuclear localization signal. The MDM4 putative nuclear localization signal, which all Mdm proteins contain, is located in the C-terminal region of the protein. The mRNA is expressed at a high level in thymus and at lower levels in all other tissues tested. MDM4 protein produced by in vitro translation interacts with p53 via a binding domain located in the N-terminal region of the MDM4 protein. MDM4 shows significant structural similarity to p53-binding protein MDM2. Two transcript variants, one protein-coding and the other likely not to be protein-coding, have been found for this gene. [provided by RefSeq
Other Designations
MDM4-related protein 1|Mdm4, transformed 3T3 cell double minute 4, p53 binding protein|double minute 4, human homolog of; p53-binding protein|mouse double minute 4 homolog|p53-binding protein
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