SMAD1 monoclonal antibody (M04A), clone 2A1
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More Files
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Western Blot (Cell lysate)
SMAD1 monoclonal antibody (M04A), clone 2A1 Western Blot analysis of SMAD1 expression in HeLa ( Cat # L013V1 ).
Western Blot (Cell lysate)
SMAD1 monoclonal antibody (M04A), clone 2A1. Western Blot analysis of SMAD1 expression in PC-12 ( Cat # L012V1 ).
Western Blot (Cell lysate)
SMAD1 monoclonal antibody (M04A), clone 2A1. Western Blot analysis of SMAD1 expression in NIH/3T3 ( Cat # L018V1 ).
Western Blot detection against Immunogen (76.89 KDa) .
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Specification
Product Description
Mouse monoclonal antibody raised against a full-length recombinant SMAD1.
Immunogen
SMAD1 (AAH01878.1, 1 a.a. ~ 465 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MNVTSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSCPGQPSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEVCINPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRNLGQNEPHMPLNATFPDSFQQPNSHPFPHSPNSSYPNSPGSSSSTYPHSPTSSDPGSPFQMPADTPPPAYLPPEDPMTQDGSQPMDTNMMAPPLPSEINRGDVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFTDPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNYHHGFHPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
Host
Mouse
Reactivity
Human, Mouse, Rat
Interspecies Antigen Sequence
Mouse (99)
Isotype
IgG2b Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (76.89 KDa) .
Storage Buffer
In ascites fluid
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
SMAD1 monoclonal antibody (M04A), clone 2A1 Western Blot analysis of SMAD1 expression in HeLa ( Cat # L013V1 ).Western Blot (Cell lysate)
SMAD1 monoclonal antibody (M04A), clone 2A1. Western Blot analysis of SMAD1 expression in PC-12 ( Cat # L012V1 ).Western Blot (Cell lysate)
SMAD1 monoclonal antibody (M04A), clone 2A1. Western Blot analysis of SMAD1 expression in NIH/3T3 ( Cat # L018V1 ).Western Blot (Recombinant protein)
ELISA
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Gene Info — SMAD1
Entrez GeneID
4086GeneBank Accession#
BC001878Protein Accession#
AAH01878.1Gene Name
SMAD1
Gene Alias
BSP1, JV4-1, JV41, MADH1, MADR1
Gene Description
SMAD family member 1
Omim ID
601595Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq
Other Designations
MAD, mothers against decapentaplegic homolog 1|Mad-related protein 1|SMAD, mothers against DPP homolog 1|Sma- and Mad-related protein 1|TGF-beta signaling protein 1|mothers against DPP homolog 1|transforming growth factor-beta signaling protein 1
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Interactome
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Pathway
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Disease
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