ALAD 293T Cell Transient Overexpression Lysate(Denatured)
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-ALAD full-length
Host
Human
Theoretical MW (kDa)
37.2
Interspecies Antigen Sequence
Mouse (89); Rat (88)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-ALAD antibody (H00000210-B01) by Western Blots.
SDS-PAGE Gel
ALAD transfected lysate
Western Blot
Lane 1: ALAD transfected lysate ( 37.2 KDa).
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — ALAD
Entrez GeneID
210GeneBank Accession#
NM_000031Protein Accession#
NP_000022Gene Name
ALAD
Gene Alias
ALADH, MGC5057, PBGS
Gene Description
aminolevulinate, delta-, dehydratase
Omim ID
125270Gene Ontology
HyperlinkGene Summary
The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway; zinc is essential for enzymatic activity. ALAD enzymatic activity is inhibited by lead and a defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria. [provided by RefSeq
Other Designations
aminolevulinate dehydratase|delta-aminolevulinic acid dehydratase|porphobilinogen synthase
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Interactome
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Pathway
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Disease
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