ALAD (Human) Recombinant Protein (Q01)
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Specification
Product Description
Human ALAD partial ORF ( NP_000022, 241 a.a. - 338 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
GLALRAVDRDVREGADMLMVKPGMPYLDIVREVKDKHPDLPLAVYHVSGEFAMLWHGAQAGAFDLKAAVLEAMTAFRRAGADIIITYYTPQLLQWLKE
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
36.52
Interspecies Antigen Sequence
Mouse (87); Rat (84)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — ALAD
Entrez GeneID
210GeneBank Accession#
NM_000031Protein Accession#
NP_000022Gene Name
ALAD
Gene Alias
ALADH, MGC5057, PBGS
Gene Description
aminolevulinate, delta-, dehydratase
Omim ID
125270Gene Ontology
HyperlinkGene Summary
The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway; zinc is essential for enzymatic activity. ALAD enzymatic activity is inhibited by lead and a defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria. [provided by RefSeq
Other Designations
aminolevulinate dehydratase|delta-aminolevulinic acid dehydratase|porphobilinogen synthase
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Interactome
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Pathway
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Disease
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