ALAD purified MaxPab rabbit polyclonal antibody (D01P)
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human ALAD protein.
Immunogen
ALAD (NP_000022.2, 1 a.a. ~ 339 a.a) full-length human protein.
Sequence
MPLCPLAHAMQPQSVLHSGYFHPLLRAWQTATTTLNASNLIYPIFVTDVPDDIQPITSLPGVARYGVKRLEEMLRPLVEEGLRCVLIFGVPSRVPKDERGSAADSEESPAIEAIHLLRKTFPNLLVACDVCLCPYTSHGHCGLLSENGAFRAEESRQRLAEVALAYAKAGCQVVAPSDMMDGRVEAIKEALMAHGLGNRVSVMSYSAKFASCFYGPFRDAAKSSPAFGDRRCYQLPPGARGLALRAVDRDVREGADMLMVKPGMPYLDIVREVKDKHPDLPLAVYHVSGEFAMLWHGAQAGAFDLKAAVLEAMTAFRRAGADIIITYYTPQLLQWLKEE
Host
Rabbit
Reactivity
Human
Interspecies Antigen Sequence
Mouse (89); Rat (88)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Tissue lysate)
ALAD MaxPab rabbit polyclonal antibody. Western Blot analysis of ALAD expression in human liver.Western Blot (Transfected lysate)
Western Blot analysis of ALAD expression in transfected 293T cell line (H00000210-T02) by ALAD MaxPab polyclonal antibody.
Lane 1: ALAD transfected lysate(37.20 KDa).
Lane 2: Non-transfected lysate.
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Gene Info — ALAD
Entrez GeneID
210GeneBank Accession#
NM_000031Protein Accession#
NP_000022.2Gene Name
ALAD
Gene Alias
ALADH, MGC5057, PBGS
Gene Description
aminolevulinate, delta-, dehydratase
Omim ID
125270Gene Ontology
HyperlinkGene Summary
The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway; zinc is essential for enzymatic activity. ALAD enzymatic activity is inhibited by lead and a defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria. [provided by RefSeq
Other Designations
aminolevulinate dehydratase|delta-aminolevulinic acid dehydratase|porphobilinogen synthase
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Interactome
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Pathway
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Disease
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Publication Reference
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Vitamin D3 enhances the apoptotic response of epithelial tumors to aminolevulinate-based photodynamic therapy.
Anand S, Wilson C, Hasan T, Maytin EV.
Cancer Research 2011 Sep; 71(18):6040.
Application:WB-Ti, Human, A-431 tumor lysates.
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Vitamin D3 enhances the apoptotic response of epithelial tumors to aminolevulinate-based photodynamic therapy.
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