ALAD polyclonal antibody (A01)
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Specification
Product Description
Mouse polyclonal antibody raised against a partial recombinant ALAD.
Immunogen
ALAD (NP_000022, 241 a.a. ~ 338 a.a) partial recombinant protein with GST tag.
Sequence
GLALRAVDRDVREGADMLMVKPGMPYLDIVREVKDKHPDLPLAVYHVSGEFAMLWHGAQAGAFDLKAAVLEAMTAFRRAGADIIITYYTPQLLQWLKE
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (87); Rat (84)
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.89 KDa) .
Storage Buffer
50 % glycerol
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
ELISA
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Gene Info — ALAD
Entrez GeneID
210GeneBank Accession#
NM_000031Protein Accession#
NP_000022Gene Name
ALAD
Gene Alias
ALADH, MGC5057, PBGS
Gene Description
aminolevulinate, delta-, dehydratase
Omim ID
125270Gene Ontology
HyperlinkGene Summary
The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway; zinc is essential for enzymatic activity. ALAD enzymatic activity is inhibited by lead and a defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria. [provided by RefSeq
Other Designations
aminolevulinate dehydratase|delta-aminolevulinic acid dehydratase|porphobilinogen synthase
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Interactome
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Pathway
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Disease
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