ACVR1B 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-ACVR1B full-length
Host
Human
Theoretical MW (kDa)
56.8
Interspecies Antigen Sequence
Mouse (98); Rat (99)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-ACVR1B antibody (H00000091-D01) by Western Blots.
SDS-PAGE Gel
ACVR1B transfected lysate.
Western Blot
Lane 1: ACVR1B transfected lysate ( 56.80 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — ACVR1B
Entrez GeneID
91GeneBank Accession#
NM_004302.3Protein Accession#
NP_004293.1Gene Name
ACVR1B
Gene Alias
ACTRIB, ACVRLK4, ALK4, SKR2
Gene Description
activin A receptor, type IB
Omim ID
601300Gene Ontology
HyperlinkGene Summary
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with a cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type IB receptor, composed of 11 exons. Alternative splicing and alternative polyadenylation result in 3 fully described transcript variants. The mRNA expression of variants 1, 2, and 3 is confirmed, and a potential fourth variant contains an alternative exon 8 and lacks exons 9 through 11, but its mRNA expression has not been confirmed. [provided by RefSeq
Other Designations
activin A receptor, type II-like kinase 4|activin A type IB receptor|activin receptor-like kinase 4|serine(threonine) protein kinase receptor R2
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