ACVR1B (Human) Matched Antibody Pair
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Specifications
Product Description
This antibody pair set comes with a matched antibody pair to detect and quantify the protein level of human ACVR1B.
Reactivity
Human
Quality Control Testing
Standard curve using recombinant protein ( H00000091-Q01 ) as an analyte.
Sandwich ELISA detection sensitivity ranging from 10 ng/ml to 100 ng/ml.
Supplied Product
Antibody pair set content:
1. Capture antibody: mouse monoclonal anti-ACVR1B, IgG1 Kappa (100 ug)
2. Detection antibody: biotinylated mouse monoclonal anti-ACVR1B, IgG1 Kappa (50 ug)
*Reagents are sufficient for at least 3-5 x 96 well plates using recommended protocols.Storage Instruction
Store reagents of the antibody pair set at -20°C or lower. Please aliquot to avoid repeated freeze thaw cycle. Reagents should be returned to -20°C storage immediately after use.
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Applications
ELISA Pair (Recombinant protein)
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Gene Info — ACVR1B
Entrez GeneID
91Gene Name
ACVR1B
Gene Alias
ACTRIB, ACVRLK4, ALK4, SKR2
Gene Description
activin A receptor, type IB
Omim ID
601300Gene Ontology
HyperlinkGene Summary
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with a cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type IB receptor, composed of 11 exons. Alternative splicing and alternative polyadenylation result in 3 fully described transcript variants. The mRNA expression of variants 1, 2, and 3 is confirmed, and a potential fourth variant contains an alternative exon 8 and lacks exons 9 through 11, but its mRNA expression has not been confirmed. [provided by RefSeq
Other Designations
activin A receptor, type II-like kinase 4|activin A type IB receptor|activin receptor-like kinase 4|serine(threonine) protein kinase receptor R2
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