APOE polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against native APOE.
Immunogen
Native purified human APOE.
Host
Goat
Reactivity
Human
Specificity
This antibody reacts with human apoLipoprotein E and has negligible cross-reactivity with Type A-1 A-II, B, C-I, C-II, C-III and J apoLipoproteins. Non-specific cross-reaction of anti-apoLipoprotein antibodies with other human serum proteins is negligible.
Form
Liquid
Quality Control Testing
Antibody Reactive Against Native Purified Protein.
Recommend Usage
ELISA (1:4000-1:8000)
Western Blot (1:500-1:2000) Immunohistochemistry (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In 100 mM Na2B4O7, 75 mM NaCl, 5 mM EDTA, pH 8.0 (0.01% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry
Immunoprecipitation
Enzyme-linked Immunoabsorbent Assay
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Gene Info — APOE
Entrez GeneID
348Gene Name
APOE
Gene Alias
AD2, LPG, MGC1571, apoprotein
Gene Description
apolipoprotein E
Gene Ontology
HyperlinkGene Summary
Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq
Other Designations
apolipoprotein E3
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Interactome
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Disease
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Publication Reference
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Interplay between Basic Residues of Hepatitis C Virus Glycoprotein E2 with Viral Receptors, Neutralizing Antibodies and Lipoproteins.
Koutsoudakis G, Dragun J, Perez-Del-Pulgar S, Coto-Llerena M, Mensa L, Crespo G, Gonzalez P, Navasa M, Forns X.
PLoS One 2012 Dec; 7(12):e52651.
Application:IA, Human, Huh-7.5 cell.
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Interplay between Basic Residues of Hepatitis C Virus Glycoprotein E2 with Viral Receptors, Neutralizing Antibodies and Lipoproteins.
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