GPC3 polyclonal antibody
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More Files
- More Functions
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining using GPC3 polyclonal antibody at 10 ug/mL on human hepatocellular carcinoma tissue.
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Specification
Product Description
Sheep polyclonal antibody raised against partial recombinant GPC3.
Immunogen
Recombinant protein corresponding to C-terminus of human GPC3.
Host
Sheep
Reactivity
Human
Form
Liquid
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Recommend Usage
Western Blot (5-10 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (10 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.08% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining using GPC3 polyclonal antibody at 10 ug/mL on human hepatocellular carcinoma tissue. -
Gene Info — GPC3
Entrez GeneID
2719Gene Name
GPC3
Gene Alias
DGSX, OCI-5, SDYS, SGB, SGBS, SGBS1
Gene Description
glypican 3
Gene Ontology
HyperlinkGene Summary
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq
Other Designations
OTTHUMP00000024058|OTTHUMP00000062492|glypican proteoglycan 3
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Interactome
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Publication Reference
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Value of glypican 3 immunostaining in the diagnosis of hepatocellular carcinoma on needle biopsy.
Anatelli F, Chuang ST, Yang XJ, Wang HL.
American Journal of Clinical Pathology 2008 Aug; 130(2):219.
Application：IHC-P, Human, Human hepatocellular carcinoma.
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Expression of glypican 3 in ovarian and extragonadal germ cell tumors.
Zynger DL, Everton MJ, Dimov ND, Chou PM, Yang XJ.
American Journal of Clinical Pathology 2008 Aug; 130(2):224.
Application：IHC-P, Human, Human extragonadal germ cell cancer, ovarian cancer.
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Sulfatase 2 up-regulates glypican 3, promotes fibroblast growth factor signaling, and decreases survival in hepatocellular carcinoma.
Lai JP, Sandhu DS, Yu C, Han T, Moser CD, Jackson KK, Guerrero RB, Aderca I, Isomoto H, Garrity-Park MM, Zou H, Shire AM, Nagorney DM, Sanderson SO, Adjei AA, Lee JS, Thorgeirsson SS, Roberts LR.
Nature 2008 Apr; 47(4):1211.
Application：IF, IHC-P, WB, Human, Hep-3B, Huh7 cells, Mouse tumor.
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Value of glypican 3 immunostaining in the diagnosis of hepatocellular carcinoma on needle biopsy.
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