SLC6A3 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot of human caudate lysate showing specific immunolabeling of the ~88k SLC6A3 protein. Using SLC6A3 polyclonal antibody (Cat # PAB9597).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of SLC6A3.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to human SLC6A3.
Host
Rabbit
Theoretical MW (kDa)
88
Reactivity
Human
Form
Liquid
Purification
Affinity purification
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Immunohistochemistry (Frozen sections) (1:1000)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM HEPES, 150 mM NaCl, pH 7.5 (50% glycerol, 10% BSA)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot (Tissue lysate)
Western blot of human caudate lysate showing specific immunolabeling of the ~88k SLC6A3 protein. Using SLC6A3 polyclonal antibody (Cat # PAB9597).Immunohistochemistry (Frozen sections)
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Gene Info — SLC6A3
Entrez GeneID
6531Protein Accession#
Q01959Gene Name
SLC6A3
Gene Alias
DAT, DAT1
Gene Description
solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
Gene Ontology
HyperlinkGene Summary
The dopamine transporter (DAT1) mediates the active reuptake of dopamine from the synapse and is a principal regulator of dopaminergic neurotransmission. The DAT1 gene has been implicated in human disorders such as parkinsonism, Tourette syndrome, and substance abuse (Vandenbergh et al., 1992 [PubMed 1359373]).[supplied by OMIM
Other Designations
dopamine transporter|variable number tandem repeat (VNTR)
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Interactome
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Disease
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Publication Reference
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Striatal dopaminergic and serotonergic markers in human heroin users.
Kish SJ, Kalasinsky KS, Derkach P, Schmunk GA, Guttman M, Ang L, Adams V, Furukawa Y, Haycock JW.
Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology 2001 May; 24(5):561.
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Quantitation of tyrosine hydroxylase protein in the locus coeruleus from postmortem human brain.
Zhu M, Klimek V, Haycock JW, Ordway GA.
Journal of Neuroscience Methods 2000 Jun; 99(1-2):37.
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Elevated levels of tyrosine hydroxylase in the locus coeruleus in major depression.
Zhu MY, Klimek V, Dilley GE, Haycock JW, Stockmeier C, Overholser JC, Meltzer HY, Ordway GA.
Biological Psychiatry 1999 Nov; 46(9):1275.
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Striatal dopaminergic and serotonergic markers in human heroin users.
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