SEMA3A polyclonal antibody
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More Files
- More Functions
Western Blot
Western blots of neonatal rat brain (lane 1) and human recombinant SEMA3A chimera (95/125 kDa) (lane 2). Blots were probed with SEMA3A polyclonal antibody (Cat # PAB7868). The antibodies recognize both the 95 kDa and 125 kDa forms of the recombinant SEMA3A.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of SEMA3A.
Immunogen
A synthetic peptide corresponding to C-terminus of human SEMA3A.
Host
Rabbit
Reactivity
Human
Specificity
The sequence used has two amino acid differences from rat and mouse Sema3A, and has low homology to other semaphorin family members.
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:2000)
Western Blot (1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (50% glycerol, 1 mg/mL BSA, 0.05% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blots of neonatal rat brain (lane 1) and human recombinant SEMA3A chimera (95/125 kDa) (lane 2). Blots were probed with SEMA3A polyclonal antibody (Cat # PAB7868). The antibodies recognize both the 95 kDa and 125 kDa forms of the recombinant SEMA3A.Enzyme-linked Immunoabsorbent Assay
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Gene Info — SEMA3A
Entrez GeneID
10371Gene Name
SEMA3A
Gene Alias
Hsema-I, Hsema-III, MGC133243, SEMA1, SEMAD, SEMAIII, SEMAL, SemD, coll-1
Gene Description
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
Omim ID
603961Gene Ontology
HyperlinkGene Summary
This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease. [provided by RefSeq
Other Designations
collapsin 1|semaphorin 3A|semaphorin D|semaphorin III|semaphorin L|semaphorin-like
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Interactome
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Pathway
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Disease
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Publication Reference
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Emerging roles for semaphorins in neural regeneration.
Pasterkamp RJ, Verhaagen J.
Brain Research. Brain Research Reviews 2001 Mar; 35(1):36.
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The semaphorin genes encode a family of transmembrane and secreted growth cone guidance molecules.
Kolodkin AL, Matthes DJ, Goodman CS.
Cell 1993 Dec; 75(7):1389.
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Collapsin: a protein in brain that induces the collapse and paralysis of neuronal growth cones.
Luo Y, Raible D, Raper JA.
Cell 1993 Oct; 75(2):217.
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Emerging roles for semaphorins in neural regeneration.
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