Kcnj11 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of Kcnj11.
Immunogen
A synthetic peptide corresponding to human Kcnj11.
Sequence
ERRARFVSKKGNC
Host
Goat
Theoretical MW (kDa)
43.6
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:64000)
Western blot (0.01-0.03 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (3-5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Kcnj11 polyclonal antibody (Cat # PAB7571) (0.01 ug/mL) staining of human muscle lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Kcnj11 polyclonal antibody (Cat # PAB7571, 3.8 ug/mL) staining of paraffin embedded human pancreas. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.Enzyme-linked Immunoabsorbent Assay
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Gene Info — KCNJ11
Entrez GeneID
3767Protein Accession#
NP_034732.1Gene Name
KCNJ11
Gene Alias
BIR, HHF2, IKATP, KIR6.2, MGC133230, PHHI, TNDM3
Gene Description
potassium inwardly-rectifying channel, subfamily J, member 11
Gene Ontology
HyperlinkGene Summary
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). [provided by RefSeq
Other Designations
ATP-sensitive inward rectifier potassium channel 11|beta-cell inward rectifier subunit|inwardly rectifying potassium channel KIR6.2|potassium inwardly-rectifying channel J11
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Interactome
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Pathway
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Disease
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Publication Reference
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Local potassium signaling couples neuronal activity to vasodilation in the brain.
Filosa JA, Bonev AD, Straub SV, Meredith AL, Wilkerson MK, Aldrich RW, Nelson MT.
Nature Neuroscience 2006 Nov; 9(11):1397.
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Local potassium signaling couples neuronal activity to vasodilation in the brain.
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