ARRB2 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
ARRB2 polyclonal antibody (Cat # PAB6785) (0.3 ug/mL) staining of human brain lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
ARRB2 polyclonal antibody (Cat # PAB6785) (4 ug/mL) staining of paraffin embedded human cerebellum. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of ARRB2.
Immunogen
A synthetic peptide corresponding to internal region of human ARRB2.
Sequence
C-HDHIPLPRPQS
Host
Goat
Theoretical MW (kDa)
46.1, 44.4
Reactivity
Human, Mouse, Rat
Specificity
This antibody is expected to recognize both reported isoforms NP_004304.1 and NP_945355.1. No crossreactivity is expected with Arrestin beta 1.
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:32000)
Western Blot (0.3-1 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (4-6 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
ARRB2 polyclonal antibody (Cat # PAB6785) (0.3 ug/mL) staining of human brain lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
ARRB2 polyclonal antibody (Cat # PAB6785) (4 ug/mL) staining of paraffin embedded human cerebellum. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining.Immunoprecipitation
Enzyme-linked Immunoabsorbent Assay
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Gene Info — ARRB2
Entrez GeneID
409Protein Accession#
NP_004304.1;NP_945355.1Gene Name
ARRB2
Gene Alias
ARB2, ARR2, BARR2, DKFZp686L0365
Gene Description
arrestin, beta 2
Omim ID
107941Gene Ontology
HyperlinkGene Summary
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined. [provided by RefSeq
Other Designations
arrestin 3
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Interactome
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Pathway
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Disease
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Publication Reference
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Transduction of receptor signals by beta-arrestins.
Lefkowitz RJ, Shenoy SK.
Science 2005 Apr; 308(5721):512.
Application：IHC, WB, Human, Human cancers, Mammalian cells.
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Transduction of receptor signals by beta-arrestins.
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