UBE2L6 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
The UBE2L6 polyclonal antibody (Cat # PAB3896) is used in Western blot to detect UBE2L6 in HL-60 cell lysate.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with UBE2L6 polyclonal antibody (Cat # PAB3896) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of UBE2L6.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human UBE2L6.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:10-50)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
The UBE2L6 polyclonal antibody (Cat # PAB3896) is used in Western blot to detect UBE2L6 in HL-60 cell lysate.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with UBE2L6 polyclonal antibody (Cat # PAB3896) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. -
Gene Info — UBE2L6
Entrez GeneID
9246Protein Accession#
NP_004214;O14933Gene Name
UBE2L6
Gene Alias
MGC40331, RIG-B, UBCH8
Gene Description
ubiquitin-conjugating enzyme E2L 6
Omim ID
603890Gene Ontology
HyperlinkGene Summary
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary structure to the enzyme encoded by UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq
Other Designations
retinoic acid induced gene B protein|ubiquitin carrier protein|ubiquitin-protein ligase
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Interactome
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Pathway
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Publication Reference
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Mechanism for ubiquitylation of the leukemia fusion proteins AML1-ETO and PML-RARalpha.
Kramer OH, Muller S, Buchwald M, Reichardt S, Heinzel T.
FASEB Journal 2007 Dec; 22(5):1369.
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Mechanism for ubiquitylation of the leukemia fusion proteins AML1-ETO and PML-RARalpha.
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