Western blot analysis of EPHA3 polyclonal antibody (Cat # PAB3005) in NCI-H460 (Land 1), 293 (Land 2) cell line lysates (35 ug/lane). EPHA3 (arrow) was detected using the purified polyclonal antibody.
Formalin-fixed and paraffin-embedded human cancer tissue reacted with EPHA3 polyclonal antibody (Cat # PAB3005) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma.
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq