PTPN6 (phospho Y536) polyclonal antibody
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using PTPN6 (phospho Y536) polyclonal antibody (Cat # PAB25887).
Immunofluorescence
Immunofluorescence staining of methanol-fixed HeLa cells using PTPN6 (phospho Y536) polyclonal antibody (Cat # PAB25887).
-
Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of PTPN6.
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding Y536 of human PTPN6.
Sequence
S-E-Yp-G-N
Host
Rabbit
Theoretical MW (kDa)
68
Reactivity
Human, Mouse, Rat
Form
Liquid
Purification
Affinity chromatography
Concentration
1 mg/mL
Recommend Usage
Immunohistochemistry (1:50-1:100)
Immunofluorescence (1:100-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (without Mg2+ and Ca2+), 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using PTPN6 (phospho Y536) polyclonal antibody (Cat # PAB25887).Immunofluorescence
Immunofluorescence staining of methanol-fixed HeLa cells using PTPN6 (phospho Y536) polyclonal antibody (Cat # PAB25887). -
Gene Info — PTPN6
Entrez GeneID
5777Protein Accession#
P29350Gene Name
PTPN6
Gene Alias
HCP, HCPH, HPTP1C, PTP-1C, SH-PTP1, SHP-1, SHP-1L, SHP1
Gene Description
protein tyrosine phosphatase, non-receptor type 6
Omim ID
176883Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq
Other Designations
hematopoietic cell phosphatase|hematopoietic cell protein-tyrosine phosphatase|protein-tyrosine phosphatase 1C
-
Interactome
-
Pathway
-
Disease
-
Publication Reference
-
SHP-1 acts as a key regulator of alloresponses by modulating LFA-1-mediated adhesion in primary murine T cells.
Sauer MG, Herbst J, Diekmann U, Rudd CE, Kardinal C.
Molecular and Cell Biology 2016 Dec; 36(24):3113.
Application：Flow Cyt, Mouse, Mouse thymocytes.
-
SHP-1 acts as a key regulator of alloresponses by modulating LFA-1-mediated adhesion in primary murine T cells.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com