Products

Western Blot (Cell lysate)

Western blot analysis of UBB polyclonal antibody (Cat # PAB2409) in HeLa cell lysate. UBB (Arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

(TOP) Formalin-fixed and paraffin-embedded human hepatocellular carcinoma reacted with UBB polyclonal antibody (Cat # PAB2409) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. (BUTTOM) Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with the UBB polyclonal antibody (Cat # PAB2409) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma.

Entrez GeneID

7314

Protein Accession#

NP_061828;P62988

Gene Name

UBB

Gene Alias

FLJ25987, MGC8385

Gene Description

ubiquitin B

Omim ID

191339

Gene Ontology

Hyperlink

Gene Summary

This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin is required for ATP-dependent, nonlysosomal intracellular protein degradation of abnormal proteins and normal proteins with a rapid turnover. Ubiquitin is covalently bound to proteins to be degraded, and presumably labels these proteins for degradation. Ubiquitin also binds to histone H2A in actively transcribed regions but does not cause histone H2A degradation, suggesting that ubiquitin is also involved in regulation of gene expression. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. Aberrant form of this protein has been noticed in patients with Alzheimer's and Down syndrome. [provided by RefSeq

Other Designations

OTTHUMP00000064960|OTTHUMP00000064961|polyubiquitin B