Rabbit polyclonal antibody raised against synthetic peptide of BIRC5.
Immunogen:
A synthetic peptide corresponding to residues surrounding T117 of human BIRC5.
Host:
Rabbit
Reactivity:
Human, Mouse, Rat
Specificity:
This antibody is specific to BIRC5.
Form:
Liquid
Purification:
Affinity purification
Concentration:
1 mg/mL
Recommend Usage:
Western Blot (1:500-1:1000) Immunohistochemistry (1:50-1:100) Immunofluorescence (1:500-1:1000) ELISA (1:5000) The optimal working dilution should be determined by the end user.
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using BIRC5 polyclonal antibody (Cat # PAB18224). Peptide "+" means "peptide blocking".
Immunofluorescence
Immunofluorescence analysis of HeLa cells, using BIRC5 polyclonal antibody (Cat # PAB18224). Peptide "+" means "peptide blocking".
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors yet low in adult tissues. Antisense transcripts are involved in the regulation of this gene's expression. At least four transcript variants encoding distinct isoforms have been found for this gene, but the full-length natures of only three of them have been determined. [provided by RefSeq
Other Designations:
apoptosis inhibitor 4,baculoviral IAP repeat-containing protein 5,survivin variant 3 alpha